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Monday, August 10, 2020 | History

2 edition of Studies on carcinogen metabolizing enzymes in the rainbow trout found in the catalog.

Studies on carcinogen metabolizing enzymes in the rainbow trout

Shiu-ling Chen

Studies on carcinogen metabolizing enzymes in the rainbow trout

by Shiu-ling Chen

  • 88 Want to read
  • 7 Currently reading

Published .
Written in English

    Subjects:
  • Cytochrome P-450.,
  • Nitrosoamines -- Toxicology.,
  • Rainbow trout -- Diseases.,
  • Carcinogenesis.,
  • Liver -- Diseases.

  • Edition Notes

    Statementby Shiu-Ling Chen.
    The Physical Object
    Pagination77 leaves, bound :
    Number of Pages77
    ID Numbers
    Open LibraryOL15184973M

    1,2-dibromoethane and chloroform in the rainbow trout (Salmo gairdneri): Studies on the distribution of the nonvolatile and irreversibley bound metabolites. J. Tox. Environ Hea – Google ScholarCited by: 3. Buy Enzymes of Lipid Metabolism (Advances in Experimental Medicine and Biology) on FREE SHIPPING on qualified orders.

      Enzymes are fundamental to life. They are proteins that catalyse chemical reactions, for example in metabolic processes such as the release of energy from foods, and in cell growth and repair. Molecular Studies on Inhibitory Effects of Epilobium hirsutum L. on Drug Metabolizing CYP2B1, CYP2C1, CYP2D2 and CYP3A4 Enzymes in Rat Liver Microsomes. 19th International Symposium on Microsomes and Drug Oxidations, 12th European Regional ISSX Meeting, June , Meeting Proceedings and Abstracts, pp. xx (xx).,

    Biotransformation enzyme activities and histopathology in rainbow trout, Salmo gairdneri, treated with cadmium. 4 quatic Tox - icology. 8. 51 - Fourman, G,L.X(). Enzymes involved in metabolism of PAH by fishes and other aquatic animals: hydrolysis and conjugation enjymes or phase Il. Boca Raton, FL. CRC. Press, - -Enzymes can also have more continuous effects that lead to the persistence or overly rapid purging of a pharmaceutical agent.-Polymorphisms in drug metabolizing genes can produce different phenotypes in each of the above cases.-All of the above are correct.


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Studies on carcinogen metabolizing enzymes in the rainbow trout by Shiu-ling Chen Download PDF EPUB FB2

Studies were also performed with schistosome-infected baboons treated with Different studies have shown that CPFAs can act as potent synergists or promoters in hepatocarcinogenesis induced in rainbow trout by aflatoxin B 1 the tissue-specific distribution of carcinogen-metabolizing enzymes is an important factor in the mechanisms of Cited by: Initially, it was thought that fish lacked cytochrome Plinked monooxygenases (Brodie and Maickel, ) but studies carried out in the late ’s (Buhler, ; Buhler and Rasmusson, ; Dewaide and Henderson, ) showed livers of rainbow trout and other fishes contained these by: Characterization and induction of xenobiotic metabolizing enzyme activities in a primary culture of rainbow trout hepatocytes Article (PDF Available) in Xenobiotica 21(4) May with.

STUDIES ON THE DIGESTIVE ENZYMES OF RAINBOW TROUT-I The enzymatic actions of the extracts from the digestive organs were investigated on various growth stages of rainbow trout for the purpose of obtaining some useful knowledge on the culture of the fish. and even at a lower temperature (at 5°C) the enzymes did not lose most of their.

The disposition of naphthalene and its metabolites in the brain of rainbow trout (Salmo gairdneri) Tracy K. Collier, Margaret M. Krahn, Donald C. Malins Pages This study was designed to assess the effects of dietary carotenoid supplementation on liver and kidney xenobiotic-metabolizing enzymes in the rainbow trout.

SUMMARY Carcinoma of the urinary bladder is the most common malignancy in the Middle East and parts of Africa where schistosomiasis is a widespread problem. Much evidence supports the association between schistosomiasis and bladder cancer: this includes the geographical correlation between the two conditions, the distinctive patterns of gender and age at diagnosis, the Cited by: Duplicate lots of rainbow trout (Salmo gairdneri) were fed either control diet (CD) or ppm Aroclor (a polychlorinated biphenyl—PCB) for 3 mth followed by initiation of liver carcinomas with 20 ppb dietary aflatoxin B 1 (AFB 1) for 2 8 and 12 mth after AFB 1 treatment, fish were sampled and tumor incidence determined.

Trout that were prefed PCB showed a 45% inhibition in Cited by: Phase I and II metabolizing enzyme The cytochrome P are phase I drug metabolizing enzymes Catalyze hydroxylation/oxidation of many organic substances and drugs Can converts pro-carcinogens to carcinogens Phase I enzymes trigger phase II enzyme like glutathione s transferase Coverts phase I products to more hydrophilic moieties.

Toxicodynamics, termed pharmacodynamics in pharmacology, describes the dynamic interactions of a toxicant with a biological target and its biological effects. A biological target, also known as the site of action, can be binding proteins, ion channels, DNA, or a variety of other a toxicant enters an organism, it can interact with these receptors and produce structural or.

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Immunochemical approaches to studies of CYP1A localization and induction by xenobiotics in fish. Authors; Ingebrigtsen, K., Skaare, J.U. and Goksoyr, A. () Response of hepatic xenobiotic metabolizing enzymes in rainbow trout (Oncorhynchus mykiss) and cod (Gadus morhua) to 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD Cited by:   Rainbow trout fed ppm dibenzo(a,l)pyrene (DBP, found in tobacco smoke and other combustion products), developed tumors in the liver (%) and stomach (%).

Animals receiving ppm CHL mixed into the DBP diet developed markedly lower tumor response in liver (%) and stomach (%). Induction of three drug-metabolizing enzymes occurred in liver microsomes of mice and rats kept on softwood bedding of either red cedar, white pine, or ponderosa pine.

This induction was reversed when animals were placed on hardwood bedding composed of a mixture of beech, birch, and maple. Differences in the capacity of various beddings to induce may partially explain divergent Cited by:   Purchase Microsomes, Drug Oxidations and Chemical Carcinogenesis V2 - 1st Edition.

Print Book & E-Book. ISBNBook Edition: 1. The effect of GEO to modulate the action of phase I carcinogen-metabolizing enzymes was investigated by studying its effect on various isoforms of microsomal cytochrome P enzymes. Significant inhibition of CYP1A1, CYP1A2, and CYP2B1/2, aniline hydroxylase (an indicator of CYP2E1 activity), and aminopyrine-N-demethylase (indicator of CYP1A Cited by:   Soy Isoflavone Studies.

Phytoestrogens decrease brain calcium-binding proteins but do not alter hypothalamic androgen metabolizing enzymes in adult male rats. Effect of genistein-enriched diets on the endocrine process of gametogenesis and on reproduction efficiency of the rainbow trout Oncorhynchus mykiss.

As in Veterans and Agent Orange (VAO) and Veterans and Agent Orange: Update (Update ), this review summarizes the experimental data that serves as a scientific basis for assessment of the biologic plausibility of health outcomes reported in epidemiologic s to establish the biologic plausibility of effects due to herbicide exposure in the laboratory strengthen the.

Dietary flavones have promising chemoprotective properties, in particular with regard to cancer, but problems with low oral bioavailability and sometimes unacceptable toxicity have made their use as protective additives to normal diets questionable. However, methylation of free phenolic hydroxyl groups leads to derivatives not susceptible to glucuronic acid or sulfate conjugation, resulting in Cited by: METABOLISING ENZYMES Metabolising enzymes for drugs and xenobiotics are differing from food metabolizing enzymes.

They are broadly classified in to two: Microsomal and Non microsomal. Microsomal enzymes catalysed majority of drug biotransformation reaction.

The large variety of microsomal enzyme catalyse oxidative, reductive & hydrolytic and glucouronidation reactions. The interaction of sodium selenite (Na/sub 2/SeO/sub 3/) and aflatoxin B/sub 1/ (AFB/sub 1/) was studied in 6-wk-old male Mongolian gerbils.

Each of four groups of gerbils were fed one of the following diets during a wk experimental period: control (commercial Chow), ppm Na/sub 2/SeO/sub 3.It reduced the carcinogenic uptake of the environmental carcinogen dibenzo[a,l]pyrene (DBP) in a controlled study of rainbow trout (Carcinogenesis, July ).] Enzymes determine the efficiency and health of the metabolic system.

They break down the nutrients in food so they can be used by the body and they are behind most of the chemical.Moreover, the book deals with genotoxicity studies and toxicological interactions of environmental chemicals and mechanisms of mutagenicity and tumor formation. The construction of genetically engineered mammalian cells for the production of a specific P isozyme and the application of these cell lines in drug metabolism, mutagenicity and.